Neural Physiology
Help Questions
Anatomy › Neural Physiology
Which of the following neurotransmitters generally has an inhibitory effect on the postsynaptic neuron?
GABA
Dopamine
Serotonin
Norepinephrine
Glutamate
Explanation
GABA is the only neurotransmitter to actively suppress the formation of an action potential when binding to the dendrites on the postsynaptic neuron.
Norepinephrine, dopamine, serotonin, and glutamate have various physiological effects in different regions of the body, but all acts to stimulate the formation of an action potential.
The putamen, caudate nucleus, and globus pallidus are part of the .
basal ganglia
diencephalon
cerebellum
corpus callosum
None of these
Explanation
The basal ganglia is a structure of the cerebrum that contains grey matter called the putamen, caudate nucleus, and globus pallidus. There are also two midbrain structures called the subthalamic nucleus and substantia nigra.
What are the two gates of the voltage-gated channels along the axonal plasma membrane?
Activation and inactivation
Activation and reactivation
and
Positive and negative
Explanation
The voltage-gated channels along the axonal plasma membrane open and close in response to changes in voltage, and may exist in three distinct states: deactivated, activated, and inactivated. While the axon is at rest, these channels are said to be deactivated; they are impermeable to sodium ions since their activation gates are closed. Once the neuron gets depolarized to the threshold of the voltage-gated sodium channels, the activation gates open, allowing the influx of sodium down its concentration gradient into the cell. During this time the channels are in their activated state. At the peak of the action potential the activation gates are still open, but the inactivation gates close, stopping the flow of sodium through the channels. The channels are in the inactivated state due to the cell becoming depolarized. Once the membrane potential drops back down towards resting, the inactivation gates open, and the activation gates close, thereby deactivating the channels again, until another action potential depolarizes the membrane.
Which of the following is NOT a property of neurons?
Undergo reactive gliosis in response to injury
Permanent cells
Cells do not divide during adulthood
Compose the nervous system
Explanation
Neurons are the cells that make up the nervous system. Neurons are large, permanent cells that do not divide during adulthood and spend most of their lives in the G0 phase of the cell cycle. If part of a neuron is damaged, it undergoes Wallerian degeneration, meaning that the neuron degenerates distal to the injury, and does not undergo reactive gliosis in response to injury. Astrocytes, a type of glial cell, do this.
Which of the following support cells myelinates the axons of the peripheral nervous system?
Schwann cells
Oligodendrocytes
Ependymal cells
Astrocytes
Explanation
There are two types of support cells that myelinate axons in the nervous system: oligodendrocytes and Schwann cells. The difference between these two cell types is their location in the nervous system. Oligodendrocytes myelinate axons in the central nervous system, and Schwann cells myelinate axons in the peripheral nervous system.
Ependymal cells secrete cerebrospinal fluid and astrocytes help form and regulate the blood-brain barrier.
Atropine is a molecule that is an antagonist to muscarinic cholinergic receptors. Based on your knowledge of autonomic nervous system physiology, how would you expect the pupils to respond to topical administration of atropine?
You will observe mydriasis (pupil dilation)
You will observe miosis (pupil constriction)
There will be no change in pupil size because the pupils do not have muscarinic receptors
The iris sphincter muscles would experience a relaxed paralysis
The iris sphincter muscles would experience a contracted paralysis
Explanation
The pupillary sphincter muscles contain muscarinic cholinergic receptors that help the eyes to respond to parasympathetic tone. When this parasympathetic signal is blocked (antagonized) via atropine, you will observe a "sympathetic response" at the level of the pupil. In this scenario, you would observe the sympathetic response of pupil dilation. Hint: "aTROP'ine" and "seeing a TROPical setting" both cause your pupils to dilate nice and wide!
How is the parasympathetic branch of the autonomic nervous system organized?
Long preganglionic fiber, short postganglionic fiber
Short preganglionic fiber, long postganglionic fiber
Short preganglionic fiber, short postganglionic fiber
Long preganglionic fiber, long postganglionic fiber
Explanation
Cell bodies of preganglionic neurons are located in the central nervous system (CNS); they synapse onto autonomic ganglia. Parasympathetic ganglia are located in or near the effector organs giving them long preganglionic fibers and short postganglionic fiber. Sympathetic ganglia are located in the paravertebral chain, thus they have short preganglionic fibers and long postganglionic fibers.
Where do the nuclei of the parasympathetic nervous system originate?
Craniosacral region (cranial nerves and S2-S4)
Thoracolumbar (T1-L3) and S2-S4
S2-S4 only
Thoracolumbar region (T1-L3)
Explanation
Preganglionic neurons of the parasympathetic nervous system originate in the nuclei of the craniosacral region (cranial nerves and in the spinal cord segments of S2-S4). Those of the sympathetic nervous system originate in the thoracolumbar region (spinal cord segments of T1-L3).
The putamen, caudate nucleus, and globus pallidus are part of the .
basal ganglia
diencephalon
cerebellum
corpus callosum
None of these
Explanation
The basal ganglia is a structure of the cerebrum that contains grey matter called the putamen, caudate nucleus, and globus pallidus. There are also two midbrain structures called the subthalamic nucleus and substantia nigra.
The autonomic nervous system consists of three divisions.
Which of the following is not a division of the autonomic system?
Somatic
Sympathetic
Parasympathetic
Enteric
Explanation
The autonomic nervous system (ANS) consists of a set of pathways to and from the central nervous system (CNS) that innervate and regulate smooth muscle, cardiac muscle, and glands. The ANS is distinct from the somatic nervous system, which innervates skeletal muscle. The ANS has three divisions the sympathetic, parasympathetic, and enteric nervous systems.