Viruses and Other Microorganisms
Help Questions
NCLEX-PN › Viruses and Other Microorganisms
Herpes virus can be detected by the Tzanck smear of the skin lesion. This test stains for the presence of which one of the following?
Multinucleated giant cells
Inclusion bodies
Dead cells
Herpes DNA
Herpes cell envelope
Explanation
The Tzanck smear stains for the presence of multinucleated giant cells that are formed as a result of fusion of cell membranes due to insertion of viral proteins into the membrane. Tzanck smear does not detect the presence of inclusion bodies, dead cells, herpes DNA, or cell envelope.
Which of the following is true of human adenoviruses?
Encodes for its own DNA polymerase.
They are enveloped viruses with helical nucleocapsid.
Genome consists of a circular single stranded RNA.
Forms acidophilic intracytoplasmic inclusions.
Replication occurs in the cytoplasm.
Explanation
Adenoviruses are non-enveloped viruses with an icosahedral nucleocapsid. The capsid contains 12 pentons at each vertices with 12 fibers projecting from the vertices. The genome is a linear double stranded DNA with terminal protein. Viral attachment proteins are present in the fibers projecting from the vertices of the virions.
The additional characteristics of adenovirus include the following:
- The virions replicate in the nucleus
- Encode proteins to promote mRNA and DNA synthesis, including its own DNA polymerase
- Infects epithelial cells lining respiratory and enteric organs
- Virus can become latent in lymphoid tissue and can be reactivated by immunosuppression or infection with other agents
- Forms basophilic intranuclear inclusions within an infected epithelial cell
Last, they are commonly associated with respiratory diseases, adenoviral pneumonia, epidemic keratoconjunctivitis, and pharyngoconjunctival fever.
Which of the following is true of human adenoviruses?
Encodes for its own DNA polymerase.
They are enveloped viruses with helical nucleocapsid.
Genome consists of a circular single stranded RNA.
Forms acidophilic intracytoplasmic inclusions.
Replication occurs in the cytoplasm.
Explanation
Adenoviruses are non-enveloped viruses with an icosahedral nucleocapsid. The capsid contains 12 pentons at each vertices with 12 fibers projecting from the vertices. The genome is a linear double stranded DNA with terminal protein. Viral attachment proteins are present in the fibers projecting from the vertices of the virions.
The additional characteristics of adenovirus include the following:
- The virions replicate in the nucleus
- Encode proteins to promote mRNA and DNA synthesis, including its own DNA polymerase
- Infects epithelial cells lining respiratory and enteric organs
- Virus can become latent in lymphoid tissue and can be reactivated by immunosuppression or infection with other agents
- Forms basophilic intranuclear inclusions within an infected epithelial cell
Last, they are commonly associated with respiratory diseases, adenoviral pneumonia, epidemic keratoconjunctivitis, and pharyngoconjunctival fever.
Herpes virus can be detected by the Tzanck smear of the skin lesion. This test stains for the presence of which one of the following?
Multinucleated giant cells
Inclusion bodies
Dead cells
Herpes DNA
Herpes cell envelope
Explanation
The Tzanck smear stains for the presence of multinucleated giant cells that are formed as a result of fusion of cell membranes due to insertion of viral proteins into the membrane. Tzanck smear does not detect the presence of inclusion bodies, dead cells, herpes DNA, or cell envelope.
An epidemiologist at a school of public health of a major medical school examined data from several studies performed by microbiologist. The data set included information about the nature of the etiological agent (virus, rickettsia, chlamydia, viroid), the nature of the genome (DNA or RNA), and whether the agent is obligate intracellular or parasitic. The epidemiologist wishes to determine which features pertain to each disease agent. Which of the following properties is unique to viruses alone?
Which of the following properties is unique to viruses alone?
Presence of an RNA genome
Obligate intracellular
Parasitic
Presence of DNA genome
Extracellular
Explanation
Rickettsia, chlamydia, prions, and viroids can be distinguished from viruses, but not by just one of the mentioned criteria. While all of these groups are obligate intracellular organisms, only the viruses are parasites with an absolute intracellular requirement, which also depend on the machinery of the host cell for replication. Prions are small infectious protein particles. Viroids are subviral infectious nucleic acids, which lack even the protein capsid found in viruses. Viruses may contain a genome of DNA or RNA, so the presence of an RNA genome is indicative of a virus, but the presence of a DNA genome is not.
An epidemiologist at a school of public health of a major medical school examined data from several studies performed by microbiologist. The data set included information about the nature of the etiological agent (virus, rickettsia, chlamydia, viroid), the nature of the genome (DNA or RNA), and whether the agent is obligate intracellular or parasitic. The epidemiologist wishes to determine which features pertain to each disease agent. Which of the following properties is unique to viruses alone?
Which of the following properties is unique to viruses alone?
Presence of an RNA genome
Obligate intracellular
Parasitic
Presence of DNA genome
Extracellular
Explanation
Rickettsia, chlamydia, prions, and viroids can be distinguished from viruses, but not by just one of the mentioned criteria. While all of these groups are obligate intracellular organisms, only the viruses are parasites with an absolute intracellular requirement, which also depend on the machinery of the host cell for replication. Prions are small infectious protein particles. Viroids are subviral infectious nucleic acids, which lack even the protein capsid found in viruses. Viruses may contain a genome of DNA or RNA, so the presence of an RNA genome is indicative of a virus, but the presence of a DNA genome is not.
What is an infectious cause of orchitis?
Mumps
Chlamydia
Measles
Epstein-Barr virus
Explanation
Orchitis due to mumps has decreased significantly due to vaccination, but it is still a significant risk in unvaccinated individuals. Mumps-related orchitis can result in testicular failure later in life. None of the other microbial infections listed have an association with orchitis.
What mold produces aflatoxin, a common contaminant in peanuts, peanut butter, pistachios, brazil nuts, and corn products?
Aspergillus
Mucor
Penicillium
Cladosporium
Explanation
Aspergillus flavus is a mold species commonly found in peanut butter and many other foods. It produces aflatoxin, a toxin linked to increased risk of liver cell cancer. The other mold species listed are not considered to be related to liver cancer. Cladosporium species are rarely harmful to humans. Penicillium species produce antibiotics, which we commonly use to treat infections. Mucor species cannot grow in warm temperatures, and are unable to infect humans, with the exception of certain heat-tolerant strains, which may cause some zygomycosis.
What is an infectious cause of orchitis?
Mumps
Chlamydia
Measles
Epstein-Barr virus
Explanation
Orchitis due to mumps has decreased significantly due to vaccination, but it is still a significant risk in unvaccinated individuals. Mumps-related orchitis can result in testicular failure later in life. None of the other microbial infections listed have an association with orchitis.
What mold produces aflatoxin, a common contaminant in peanuts, peanut butter, pistachios, brazil nuts, and corn products?
Aspergillus
Mucor
Penicillium
Cladosporium
Explanation
Aspergillus flavus is a mold species commonly found in peanut butter and many other foods. It produces aflatoxin, a toxin linked to increased risk of liver cell cancer. The other mold species listed are not considered to be related to liver cancer. Cladosporium species are rarely harmful to humans. Penicillium species produce antibiotics, which we commonly use to treat infections. Mucor species cannot grow in warm temperatures, and are unable to infect humans, with the exception of certain heat-tolerant strains, which may cause some zygomycosis.