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Ubiquitin-mediated degradation of IkB, causing a conformational shift in NFkB that renders its DNA-binding domain inaccessible

Recruitment of transcription factors and coactivators of transcription to the cytoplasmically sequestered NFkB

Ubiquitin-mediated degradation of NFkB

Ubiquitin-mediated degradation of IkB, allowing NFkB to translocate to the nucleus and initiate transcription

Ubiquitin-mediated degradation of NFkB, allowing IkB to translocate to the nucleus and initiate transcription