Test: GRE Subject Test: Biochemistry, Cell, and Molecular Biology

1.

Which of the following mutations in the EGF pathway could lead to increased proliferation of cells?

Mutation blocking EGF binding to EGFR

Mutation causing constitutively phosphorylated Erk

Mutation abolishing kinase activity of RAF

Mutation introducing hydrophillic domains in the hydrophobic region of EGFR 

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